record state
frontier-ownedReview status
This finding is part of accepted frontier state. Review events, reviewable changes, and proof state explain how it can change.
unreviewed
frontiers / frontier
Finding bundle
back to stateno incoming links yet
record state
frontier-ownedThis finding is part of accepted frontier state. Review events, reviewable changes, and proof state explain how it can change.
finding statement
finding type[object Object] · [object Object] · [object Object]
evidence
source-boundobservational · manual state transition
proof impact
packet context5 reviewable changes and 0 evaluation records are attached to this finding id.
Evidence and conditions
method
manual state transition
evidence type
observational
evidence spans
Cerebral microvasculature in early Alzheimer's disease post-mortem brain shows reduced expression of tight-junction proteins claudin-5 and occludin. Loss of these tight-junction components is consistent with a shared mechanism of blood-brain barrier compromise observed in other CNS pathologies including peritumoral glioma vasculature.
Yamazaki 2019 abstract / Carrano 2011 Figure 3
conditions
Provenance
source title
Yamazaki et al., Brain 2019; Carrano et al., Antioxid Redox Signal 2011
authors
agent:bbb-curation-bot-2026-05-09
Cerebral microvasculature in early Alzheimer's disease post-mortem brain shows reduced expression of tight-junction proteins claudin-5 and occludin. Loss of these tight-junction components is consistent with a shared mechanism of blood-brain barrier compromise observed in other CNS pathologies including peritumoral glioma vasculature.
vs_80b7c2dc8cc0347b · section:Yamazaki 2019 abstract / Carrano 2011 Figure 3 · manual_curation
outgoing
No outgoing links.
incoming
No incoming links.
events
vev_32642dcf29862edffinding.entity_resolvedWave A.2 curation: canonical entity resolution against standard ontologies (UniProt for proteins, MeSH for cell types and anatomical structures). All identifiers are unambiguous standard mappings.
reviewer:will-blair · 2026-05-10
vev_37c6ac65d30ce3b4finding.entity_resolvedWave A.2 curation: canonical entity resolution against standard ontologies (UniProt for proteins, MeSH for cell types and anatomical structures). All identifiers are unambiguous standard mappings.
reviewer:will-blair · 2026-05-10
vev_720a56b30dbe2909finding.entity_resolvedWave A.2 curation: canonical entity resolution against standard ontologies (UniProt for proteins, MeSH for cell types and anatomical structures). All identifiers are unambiguous standard mappings.
reviewer:will-blair · 2026-05-10
vev_767b027713665378finding.assertedManual finding added to frontier state
agent:bbb-curation-bot-2026-05-09 · 2026-05-09
vev_cd144b1e7c56413afinding.span_repairedWave A.3 curation: paraphrased span anchored to Yamazaki et al. Brain 2019 (tight-junction loss in AD post-mortem) and Carrano et al. Antioxid Redox Signal 2011 (oxidative-stress-mediated BBB tight-junction breakdown). Span is curator-paraphrased; cited paper sections are the load-bearing ones.
reviewer:will-blair · 2026-05-10
reviewable changes
vpr_21d0c76335044d59finding.entity_resolveWave A.2 curation: canonical entity resolution against standard ontologies (UniProt for proteins, MeSH for cell types and anatomical structures). All identifiers are unambiguous standard mappings.
applied · reviewer:will-blair · 2026-05-10
vpr_5d60f1d220d27332finding.entity_resolveWave A.2 curation: canonical entity resolution against standard ontologies (UniProt for proteins, MeSH for cell types and anatomical structures). All identifiers are unambiguous standard mappings.
applied · reviewer:will-blair · 2026-05-10
vpr_647281164d2a42d4finding.addManual finding added to frontier state
applied · agent:bbb-curation-bot-2026-05-09 · 2026-05-09
vpr_89fb94bdd3aee792finding.entity_resolveWave A.2 curation: canonical entity resolution against standard ontologies (UniProt for proteins, MeSH for cell types and anatomical structures). All identifiers are unambiguous standard mappings.
applied · reviewer:will-blair · 2026-05-10
vpr_c43731aea1eb7545finding.span_repairWave A.3 curation: paraphrased span anchored to Yamazaki et al. Brain 2019 (tight-junction loss in AD post-mortem) and Carrano et al. Antioxid Redox Signal 2011 (oxidative-stress-mediated BBB tight-junction breakdown). Span is curator-paraphrased; cited paper sections are the load-bearing ones.
applied · reviewer:will-blair · 2026-05-10
evaluations
No evaluation record targets this finding id.