evidence boundary
supportsobservational
An evidence atom is an inspectable support unit. It is not a finding by itself; it supports or challenges a finding through review.
frontiers / frontier
Evidence atom
back to sourcesevidence boundary
supportsAn evidence atom is an inspectable support unit. It is not a finding by itself; it supports or challenges a finding through review.
finding binding
boundAtabecestat Phase II/III development halted in 2018 after liver toxicity AND cognitive worsening signal in J&J's EARLY trial; class concern about BACE inhibitor cognitive harm propagated from verubecestat APECS findings.
inspect finding →
source binding
source-boundvs_30819ebd2ee9adad
inspect source →
review context
unverified2 reviewable changes and 0 evaluation records target this atom or its bound objects.
Evidence statement
Atabecestat Phase II/III development halted in 2018 after liver toxicity AND cognitive worsening signal in J&J's EARLY trial; class concern about BACE inhibitor cognitive harm propagated from verubecestat APECS findings.
locator
source:Cascade-densification deposit: Verubecestat APECS cognitive worsening → BACE inhibitor class shutdown|section:curator_source
extraction method
manual_curation
support relation
supports
condition refs
vcnd_1b212eb6a809dbfa
Caveats
No evidence-specific caveats are recorded.
events
vev_6ca33fa1933045dffinding.reviewedAccepted as a broad-frontier seed inside the anti-amyloid scope; source locator remains the authority.
reviewer:will-blair-bot · 2026-05-06
vev_ba0843a5d0cdc4f7finding.assertedManual finding added to frontier state
reviewer:will-blair-bot · 2026-05-06
reviewable changes
vpr_94b5a2a50c20656dfinding.reviewAccepted as a broad-frontier seed inside the anti-amyloid scope; source locator remains the authority.
applied · reviewer:will-blair-bot · 2026-05-06
vpr_d86065fcd5f2931efinding.addManual finding added to frontier state
applied · reviewer:will-blair-bot · 2026-05-06
evaluations
No evaluation rows are attached.