record state
frontier-ownedReview status
This finding is part of accepted frontier state. Review events, reviewable changes, and proof state explain how it can change.
accepted
frontiers / frontier
Finding bundle
back to stateno incoming links yet
record state
frontier-ownedThis finding is part of accepted frontier state. Review events, reviewable changes, and proof state explain how it can change.
finding statement
finding typeNo entity list is declared.
evidence
source-boundobservational · manual state transition · Homo sapiens
proof impact
packet context2 reviewable changes and 0 evaluation records are attached to this finding id.
Evidence and conditions
method
manual state transition
evidence type
observational
species
Homo sapiens
evidence spans
Atabecestat Phase II/III development halted in 2018 after liver toxicity AND cognitive worsening signal in J&J's EARLY trial; class concern about BACE inhibitor cognitive harm propagated from verubecestat APECS findings.
Cascade-densification deposit: Verubecestat APECS cognitive worsening → BACE inhibitor class shutdown · curator_source · Cascade-densification deposit: Verubecestat APECS cognitive worsening → BACE inhibitor class shutdown
conditions
Provenance
source title
Cascade-densification deposit: Verubecestat APECS cognitive worsening → BACE inhibitor class shutdown
authors
reviewer:will-blair-bot
Atabecestat Phase II/III development halted in 2018 after liver toxicity AND cognitive worsening signal in J&J's EARLY trial; class concern about BACE inhibitor cognitive harm propagated from verubecestat APECS findings.
vs_30819ebd2ee9adad · source:Cascade-densification deposit: Verubecestat APECS cognitive worsening → BACE inhibitor class shutdown|section:curator_source · manual_curation
outgoing
No outgoing links.
incoming
No incoming links.
events
vev_6ca33fa1933045dffinding.reviewedAccepted as a broad-frontier seed inside the anti-amyloid scope; source locator remains the authority.
reviewer:will-blair-bot · 2026-05-06
vev_ba0843a5d0cdc4f7finding.assertedManual finding added to frontier state
reviewer:will-blair-bot · 2026-05-06
reviewable changes
vpr_94b5a2a50c20656dfinding.reviewAccepted as a broad-frontier seed inside the anti-amyloid scope; source locator remains the authority.
applied · reviewer:will-blair-bot · 2026-05-06
vpr_d86065fcd5f2931efinding.addManual finding added to frontier state
applied · reviewer:will-blair-bot · 2026-05-06
evaluations
No evaluation record targets this finding id.