evidence boundary
supportsexperimental
An evidence atom is an inspectable support unit. It is not a finding by itself; it supports or challenges a finding through review.
frontiers / frontier
Evidence atom
back to sourcesevidence boundary
supportsAn evidence atom is an inspectable support unit. It is not a finding by itself; it supports or challenges a finding through review.
finding binding
boundVerubecestat APECS trial in prodromal AD also failed; cognitive worsening replicated in the earlier-stage population. Class concern about BACE1 inhibitor cognitive harm — likely off-target via non-APP BACE1 substrates (e.g. neuregulin-1, seizure protein 6).
inspect finding →
source binding
source-boundvs_a8e8c2eb2c0cc3c9
inspect source →
review context
unverified1 reviewable changes and 0 evaluation records target this atom or its bound objects.
Evidence statement
Verubecestat APECS trial in prodromal AD also failed; cognitive worsening replicated in the earlier-stage population. Class concern about BACE1 inhibitor cognitive harm — likely off-target via non-APP BACE1 substrates (e.g. neuregulin-1, seizure protein 6).
locator
source:Michael Egan; James Kost; Tiffini Voss; Yuki Mukai; Paul Aisen; Jeffrey L. Cummings; Pierre N. Tariot; Bruno Vellas. New England Journal of Medicine 2019. doi:10.1056/NEJMoa1812840|section:curator_source
extraction method
manual_curation
support relation
supports
condition refs
vcnd_5692f66b810d727a
Caveats
No evidence-specific caveats are recorded.
events
vev_e9f2a28ca4fa2c24finding.assertedManual finding added to frontier state
reviewer:will-blair-bot · 2026-05-06
reviewable changes
vpr_f2b468ec2f316fdffinding.addManual finding added to frontier state
applied · reviewer:will-blair-bot · 2026-05-06
evaluations
No evaluation rows are attached.