source boundary
frontier-owneddeclared
A source record is provenance. It supports a finding only through evidence atoms, extraction spans, and reviewed finding bundles.
frontiers / frontier
Source record
back to sourcessource boundary
frontier-ownedA source record is provenance. It supports a finding only through evidence atoms, extraction spans, and reviewed finding bundles.
finding bindings
record contextFindings bound to this source through source ids, evidence atoms, provenance, or reviewed source-record slots.
evidence atoms
materializedEvidence atoms pin exact spans, measurements, selectors, or curation assertions to the source.
review context
inspectable3 reviewable changes and 0 evaluations are attached through this source or its findings.
Locator and citation
external sourcelocator
doi:10.1056/NEJMoa1812840
doi
10.1056/NEJMoa1812840
pmid
30970186
imported
2026-05-06T03:57:52.114267+00:00
extraction mode
manual_curation
journal
New England Journal of Medicine
authors
Michael Egan, James Kost, Tiffini Voss, Yuki Mukai, Paul Aisen, Jeffrey L. Cummings, Pierre N. Tariot, Bruno Vellas
Caveats
No source-specific caveats are recorded.
negative · vf_247ab84f7a601b89
therapeutic · vf_75102bc7f536a410
Verubecestat APECS trial in prodromal AD also failed; cognitive worsening replicated in the earlier-stage population. Class concern about BACE1 inhibitor cognitive harm — likely off-target via non-APP BACE1 substrates (e.g. neuregulin-1, seizure protein 6).
events
vev_184863467acbd051finding.assertedManual finding added to frontier state
reviewer:will-blair-bot · 2026-05-06
vev_7d84b9426da6336cfinding.reviewedReviewed as amyloid-pathway translation tension, not as a direct antibody contradiction.
reviewer:will-blair-bot · 2026-05-06
vev_e9f2a28ca4fa2c24finding.assertedManual finding added to frontier state
reviewer:will-blair-bot · 2026-05-06
reviewable changes
vpr_47f4147afcd7c0abfinding.reviewReviewed as amyloid-pathway translation tension, not as a direct antibody contradiction.
applied · reviewer:will-blair-bot · 2026-05-06
vpr_a901f7375eedf9befinding.addManual finding added to frontier state
applied · reviewer:will-blair-bot · 2026-05-06
vpr_f2b468ec2f316fdffinding.addManual finding added to frontier state
applied · reviewer:will-blair-bot · 2026-05-06
evaluations
No evaluation rows are attached.