record state
frontier-ownedReview status
This finding is part of accepted frontier state. Review events, reviewable changes, and proof state explain how it can change.
contested
frontiers / frontier
Finding bundle
back to staterecord state
frontier-ownedThis finding is part of accepted frontier state. Review events, reviewable changes, and proof state explain how it can change.
finding statement
finding type[object Object] · [object Object] · [object Object] · [object Object]
evidence
source-boundexperimental · manual state transition; placebo-controlled clinical trial where source reports control arm · Homo sapiens
proof impact
packet context2 reviewable changes and 0 evaluation records are attached to this finding id.
Evidence and conditions
method
manual state transition; placebo-controlled clinical trial where source reports control arm
evidence type
experimental
species
Homo sapiens
evidence spans
Verubecestat failed in prodromal Alzheimer's disease and raised concern that BACE1 inhibition can worsen cognition.
Egan et al. 2019 NEJM, APECS · curator_source · 10.1056/NEJMoa1812840
conditions
Provenance
source title
Egan et al. 2019 NEJM, APECS
doi
10.1056/NEJMoa1812840
journal
New England Journal of Medicine
authors
reviewer:will-blair-bot
source record
declaredvs_5267252f5625711bdoi:10.1056/NEJMoa1812840 · 10.1056/NEJMoa1812840
inspect source →
source record
declaredvs_a8e8c2eb2c0cc3c9doi:10.1056/NEJMoa1812840 · 10.1056/NEJMoa1812840 · 30970186
inspect source →
Verubecestat failed in prodromal Alzheimer's disease and raised concern that BACE1 inhibition can worsen cognition.
vs_5267252f5625711b · source:Egan et al. 2019 NEJM, APECS|section:curator_source · manual_curation
outgoing
vf_03875dbe6be66b00prodromal failure reinforces EPOCH class concern
vf_afddbeabc19efa09prodromal BACE inhibition weakens simple amyloid-lowering translation
incoming
No incoming links.
events
vev_184863467acbd051finding.assertedManual finding added to frontier state
reviewer:will-blair-bot · 2026-05-06
vev_7d84b9426da6336cfinding.reviewedReviewed as amyloid-pathway translation tension, not as a direct antibody contradiction.
reviewer:will-blair-bot · 2026-05-06
reviewable changes
vpr_47f4147afcd7c0abfinding.reviewReviewed as amyloid-pathway translation tension, not as a direct antibody contradiction.
applied · reviewer:will-blair-bot · 2026-05-06
vpr_a901f7375eedf9befinding.addManual finding added to frontier state
applied · reviewer:will-blair-bot · 2026-05-06
evaluations
No evaluation record targets this finding id.