record state
frontier-ownedReview status
This finding is part of accepted frontier state. Review events, reviewable changes, and proof state explain how it can change.
under review
frontiers / frontier
Finding bundle
back to staterecord state
frontier-ownedThis finding is part of accepted frontier state. Review events, reviewable changes, and proof state explain how it can change.
finding statement
finding type[object Object] · [object Object] · [object Object] · [object Object]
evidence
source-boundcase_report · manual state transition · Homo sapiens
proof impact
packet context3 reviewable changes and 0 evaluation records are attached to this finding id.
Evidence and conditions
method
manual state transition
evidence type
case_report
species
Homo sapiens
evidence spans
Focused ultrasound blood-brain barrier opening may increase regional amyloid removal during aducanumab treatment, but current human evidence is very small and not sufficient for clinical translation.
Focused ultrasound with aducanumab human pilot · curator_source · 10.1056/NEJMoa2308719
conditions
Provenance
source title
Focused ultrasound with aducanumab human pilot
doi
10.1056/NEJMoa2308719
journal
New England Journal of Medicine
authors
reviewer:will-blair-bot
Focused ultrasound blood-brain barrier opening may increase regional amyloid removal during aducanumab treatment, but current human evidence is very small and not sufficient for clinical translation.
vs_7299bf391a93510b · source:Focused ultrasound with aducanumab human pilot|section:curator_source · manual_curation
outgoing
vf_f738e7618b5339b8delivery enhancement changes regional amyloid-removal interpretation
incoming
No incoming links.
events
vev_04967ad4df49dd95finding.confidence_revisedSmall pilot evidence lowers translation confidence until replicated.
reviewer:will-blair-bot · 2026-05-06
vev_35103f7f0b3d0dcefinding.reviewedVery small human sample; delivery signal should not be generalized.
reviewer:will-blair-bot · 2026-05-06
vev_4d144ddf5883a140finding.assertedManual finding added to frontier state
reviewer:will-blair-bot · 2026-05-06
reviewable changes
vpr_26b5501c9e58397bfinding.addManual finding added to frontier state
applied · reviewer:will-blair-bot · 2026-05-06
vpr_4c253b0b824aafb2finding.reviewVery small human sample; delivery signal should not be generalized.
applied · reviewer:will-blair-bot · 2026-05-06
vpr_b4d3f58f831da9f6finding.confidence_reviseSmall pilot evidence lowers translation confidence until replicated.
applied · reviewer:will-blair-bot · 2026-05-06
evaluations
No evaluation record targets this finding id.