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Anti-amyloid translation in Alzheimer's disease

CC-BY-4.0vfr_5076e7b3ff8e6b0f

id: vfr_5076e7b3ff8e6b0f
license: CC-BY-4.0
findings: 144
accepted core: 44
contested: 9

144

findings

links

125

sources

147

evidence

contested

0.63

avg conf

frontiers / frontier

Anti-amyloid translation in Alzheimer's disease

CC-BY-4.0vfr_5076e7b3ff8e6b0f

id: vfr_5076e7b3ff8e6b0f
license: CC-BY-4.0
findings: 144
accepted core: 44
contested: 9

144

findings

links

125

sources

147

evidence

contested

0.63

avg conf

Source record

back to sources

Focused ultrasound with aducanumab human pilot

id: vs_7299bf391a93510b
frontier: Anti-amyloid translation in Alzheimer's disease
year: 2024
type: paper

source boundary

frontier-owned

declared

A source record is provenance. It supports a finding only through evidence atoms, extraction spans, and reviewed finding bundles.

finding bindings

record context

1 findings

Findings bound to this source through source ids, evidence atoms, provenance, or reviewed source-record slots.

evidence atoms

materialized

1 atoms

Evidence atoms pin exact spans, measurements, selectors, or curation assertions to the source.

review context

inspectable

3 events

3 reviewable changes and 0 evaluations are attached through this source or its findings.

Locator and citation

external source

locator

doi:10.1056/NEJMoa2308719

doi

10.1056/NEJMoa2308719

imported

2026-05-06T03:57:47.306582+00:00

extraction mode

manual_curation

journal

New England Journal of Medicine

authors

reviewer:will-blair-bot

Caveats

No source-specific caveats are recorded.

Bound findings

Focused ultrasound blood-brain barrier opening may increase regional amyloid removal during aducanumab treatment, but current human evidence is very small and not sufficient for clinical translation.
therapeutic · vf_56f893a9fe9651de

Evidence atoms

vea_08c6ba78e3eb3f52case_report · supports
Focused ultrasound blood-brain barrier opening may increase regional amyloid removal during aducanumab treatment, but current human evidence is very small and not sufficient for clinical translation.

Review, event, and evaluation records

events

vev_04967ad4df49dd95finding.confidence_revised
Small pilot evidence lowers translation confidence until replicated.
reviewer:will-blair-bot · 2026-05-06
vev_35103f7f0b3d0dcefinding.reviewed
Very small human sample; delivery signal should not be generalized.
reviewer:will-blair-bot · 2026-05-06
vev_4d144ddf5883a140finding.asserted
Manual finding added to frontier state
reviewer:will-blair-bot · 2026-05-06

reviewable changes

vpr_26b5501c9e58397bfinding.add
Manual finding added to frontier state
applied · reviewer:will-blair-bot · 2026-05-06
vpr_4c253b0b824aafb2finding.review
Very small human sample; delivery signal should not be generalized.
applied · reviewer:will-blair-bot · 2026-05-06
vpr_b4d3f58f831da9f6finding.confidence_revise
Small pilot evidence lowers translation confidence until replicated.
applied · reviewer:will-blair-bot · 2026-05-06

evaluations

No evaluation rows are attached.

Source record

back to sources

Focused ultrasound with aducanumab human pilot

id: vs_7299bf391a93510b
frontier: Anti-amyloid translation in Alzheimer's disease
year: 2024
type: paper

source boundary

frontier-owned

declared

A source record is provenance. It supports a finding only through evidence atoms, extraction spans, and reviewed finding bundles.

finding bindings

record context

1 findings

Findings bound to this source through source ids, evidence atoms, provenance, or reviewed source-record slots.

evidence atoms

materialized

1 atoms

Evidence atoms pin exact spans, measurements, selectors, or curation assertions to the source.

review context

inspectable

3 events

3 reviewable changes and 0 evaluations are attached through this source or its findings.

Locator and citation

external source

locator

doi:10.1056/NEJMoa2308719

doi

10.1056/NEJMoa2308719

imported

2026-05-06T03:57:47.306582+00:00

extraction mode

manual_curation

journal

New England Journal of Medicine

authors

reviewer:will-blair-bot

Caveats

No source-specific caveats are recorded.

Bound findings

Focused ultrasound blood-brain barrier opening may increase regional amyloid removal during aducanumab treatment, but current human evidence is very small and not sufficient for clinical translation.
therapeutic · vf_56f893a9fe9651de

Evidence atoms

vea_08c6ba78e3eb3f52case_report · supports
Focused ultrasound blood-brain barrier opening may increase regional amyloid removal during aducanumab treatment, but current human evidence is very small and not sufficient for clinical translation.

Review, event, and evaluation records

events

vev_04967ad4df49dd95finding.confidence_revised
Small pilot evidence lowers translation confidence until replicated.
reviewer:will-blair-bot · 2026-05-06
vev_35103f7f0b3d0dcefinding.reviewed
Very small human sample; delivery signal should not be generalized.
reviewer:will-blair-bot · 2026-05-06
vev_4d144ddf5883a140finding.asserted
Manual finding added to frontier state
reviewer:will-blair-bot · 2026-05-06

reviewable changes

vpr_26b5501c9e58397bfinding.add
Manual finding added to frontier state
applied · reviewer:will-blair-bot · 2026-05-06
vpr_4c253b0b824aafb2finding.review
Very small human sample; delivery signal should not be generalized.
applied · reviewer:will-blair-bot · 2026-05-06
vpr_b4d3f58f831da9f6finding.confidence_revise
Small pilot evidence lowers translation confidence until replicated.
applied · reviewer:will-blair-bot · 2026-05-06

evaluations

No evaluation rows are attached.

vs_7299bf391a93510b · source

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declared

1 findings

1 atoms

3 events

Bound findings

Evidence atoms

Review, event, and evaluation records

declared

1 findings

1 atoms

3 events

Bound findings

Evidence atoms

Review, event, and evaluation records