record state
frontier-ownedReview status
This finding is part of accepted frontier state. Review events, reviewable changes, and proof state explain how it can change.
unreviewed
frontiers / frontier
Finding bundle
back to stateno incoming links yet
record state
frontier-ownedThis finding is part of accepted frontier state. Review events, reviewable changes, and proof state explain how it can change.
finding statement
finding type[object Object] · [object Object]
evidence
source-boundexperimental · manual state transition; control details require source inspection · source-reported model organism
proof impact
packet context1 reviewable changes and 0 evaluation records are attached to this finding id.
Evidence and conditions
method
manual state transition; control details require source inspection
evidence type
experimental
species
source-reported model organism
evidence spans
High-affinity anti-TfR antibodies remain associated with the blood-brain barrier vasculature, whereas lower-affinity variants are released into the brain parenchyma.
Boosting brain uptake of a therapeutic antibody by reducing its affinity for a transcytosis target. · curator_source · 10.1126/scitranslmed.3002230
conditions
Provenance
source title
Boosting brain uptake of a therapeutic antibody by reducing its affinity for a transcytosis target.
doi
10.1126/scitranslmed.3002230
pmid
21613623
journal
Sci Transl Med
authors
Yu YJ, Zhang Y, Kenrick M, Hoyte K, Luk W, Lu Y, Atwal J, Elliott JM
source record
declaredvs_4d751576a2378d73doi:10.1126/scitranslmed.3002230 · 10.1126/scitranslmed.3002230
inspect source →
source record
declaredvs_65b4f02d7c3e0642doi:10.1126/scitranslmed.3002230 · 10.1126/scitranslmed.3002230 · 21613623
inspect source →
source record
declaredvs_aae94d67e282b304doi:10.1126/scitranslmed.3002230 · 10.1126/scitranslmed.3002230 · 21613623
inspect source →
High-affinity anti-TfR antibodies remain associated with the blood-brain barrier vasculature, whereas lower-affinity variants are released into the brain parenchyma.
vs_aae94d67e282b304 · source:Boosting brain uptake of a therapeutic antibody by reducing its affinity for a transcytosis target.|section:curator_source · manual_curation
outgoing
No outgoing links.
incoming
No incoming links.
events
vev_310f0a38204e8575finding.assertedManual finding added to frontier state
reviewer:will-blair-bot · 2026-05-06
reviewable changes
vpr_3969c44c787e15e6finding.addManual finding added to frontier state
applied · reviewer:will-blair-bot · 2026-05-06
evaluations
No evaluation record targets this finding id.