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Anti-amyloid translation in Alzheimer's disease

CC-BY-4.0vfr_5076e7b3ff8e6b0f

id: vfr_5076e7b3ff8e6b0f
license: CC-BY-4.0
findings: 144
accepted core: 44
contested: 9

144

findings

links

125

sources

147

evidence

contested

0.63

avg conf

frontiers / frontier

Anti-amyloid translation in Alzheimer's disease

CC-BY-4.0vfr_5076e7b3ff8e6b0f

id: vfr_5076e7b3ff8e6b0f
license: CC-BY-4.0
findings: 144
accepted core: 44
contested: 9

144

findings

links

125

sources

147

evidence

contested

0.63

avg conf

Source record

back to sources

Boosting brain uptake of a therapeutic antibody by reducing its affinity for a transcytosis target.

id: vs_aae94d67e282b304
frontier: Anti-amyloid translation in Alzheimer's disease
year: 2011
type: paper

source boundary

frontier-owned

declared

A source record is provenance. It supports a finding only through evidence atoms, extraction spans, and reviewed finding bundles.

finding bindings

record context

4 findings

Findings bound to this source through source ids, evidence atoms, provenance, or reviewed source-record slots.

evidence atoms

materialized

2 atoms

Evidence atoms pin exact spans, measurements, selectors, or curation assertions to the source.

review context

inspectable

5 events

5 reviewable changes and 0 evaluations are attached through this source or its findings.

Locator and citation

external source

locator

doi:10.1126/scitranslmed.3002230

doi

10.1126/scitranslmed.3002230

pmid

21613623

imported

2026-05-06T03:57:51.167997+00:00

extraction mode

manual_curation

authors

Yu YJ, Zhang Y, Kenrick M, Hoyte K, Luk W, Lu Y, Atwal J, Elliott JM

Caveats

No source-specific caveats are recorded.

Bound findings

Covers Genentech's low-affinity anti-TfR antibodies that facilitate BBB transcytosis without inhibiting transferrin or HFE binding; foundational patent on affinity-tuning TfR antibodies to escape lysosomal trapping and achieve CNS delivery.
therapeutic · vf_806ac99cdbc7ad59
Reducing anti-TfR antibody affinity for transferrin receptor enhances receptor-mediated transcytosis and brain uptake; bispecific anti-TfR/BACE1 antibody lowers brain Aβ in mice after single systemic dose. Mechanistic foundation of the Brain Shuttle delivery class.
therapeutic · vf_a0f9919e6d163b8d
Reducing the affinity of an antibody for the transferrin receptor (TfR) enhances its receptor-mediated transcytosis across the blood-brain barrier (BBB) into the mouse brain.
mechanism · vf_c3d9e665f63f045e
High-affinity anti-TfR antibodies remain associated with the blood-brain barrier vasculature, whereas lower-affinity variants are released into the brain parenchyma.
observational · vf_c7f8be49ea6547d8

Evidence atoms

vea_00c44b9dcdd344b7experimental · supports
Reducing the affinity of an antibody for the transferrin receptor (TfR) enhances its receptor-mediated transcytosis across the blood-brain barrier (BBB) into the mouse brain.
vea_413c78fe9dd802a5experimental · supports
High-affinity anti-TfR antibodies remain associated with the blood-brain barrier vasculature, whereas lower-affinity variants are released into the brain parenchyma.

Review, event, and evaluation records

events

vev_310f0a38204e8575finding.asserted
Manual finding added to frontier state
reviewer:will-blair-bot · 2026-05-06
vev_81f5607a5bcb6152finding.asserted
Manual finding added to frontier state
reviewer:will-blair-bot · 2026-05-06
vev_82932ecc6fce6211finding.asserted
Manual finding added to frontier state
reviewer:will-blair-bot · 2026-05-06
vev_ba1237c010601c63finding.asserted
Manual finding added to frontier state
reviewer:will-blair-bot · 2026-05-06
vev_fe5601397b60c040finding.reviewed
Accepted as a broad-frontier seed inside the anti-amyloid scope; source locator remains the authority.
reviewer:will-blair-bot · 2026-05-06

reviewable changes

vpr_073fe27e3062e803finding.review
Accepted as a broad-frontier seed inside the anti-amyloid scope; source locator remains the authority.
applied · reviewer:will-blair-bot · 2026-05-06
vpr_16a864c07facc4b8finding.add
Manual finding added to frontier state
applied · reviewer:will-blair-bot · 2026-05-06
vpr_1baa2624cf41beccfinding.add
Manual finding added to frontier state
applied · reviewer:will-blair-bot · 2026-05-06
vpr_3969c44c787e15e6finding.add
Manual finding added to frontier state
applied · reviewer:will-blair-bot · 2026-05-06
vpr_eb5bb753c55ac69cfinding.add
Manual finding added to frontier state
applied · reviewer:will-blair-bot · 2026-05-06

evaluations

No evaluation rows are attached.

Source record

back to sources

Boosting brain uptake of a therapeutic antibody by reducing its affinity for a transcytosis target.

id: vs_aae94d67e282b304
frontier: Anti-amyloid translation in Alzheimer's disease
year: 2011
type: paper

source boundary

frontier-owned

declared

A source record is provenance. It supports a finding only through evidence atoms, extraction spans, and reviewed finding bundles.

finding bindings

record context

4 findings

Findings bound to this source through source ids, evidence atoms, provenance, or reviewed source-record slots.

evidence atoms

materialized

2 atoms

Evidence atoms pin exact spans, measurements, selectors, or curation assertions to the source.

review context

inspectable

5 events

5 reviewable changes and 0 evaluations are attached through this source or its findings.

Locator and citation

external source

locator

doi:10.1126/scitranslmed.3002230

doi

10.1126/scitranslmed.3002230

pmid

21613623

imported

2026-05-06T03:57:51.167997+00:00

extraction mode

manual_curation

authors

Yu YJ, Zhang Y, Kenrick M, Hoyte K, Luk W, Lu Y, Atwal J, Elliott JM

Caveats

No source-specific caveats are recorded.

Bound findings

Covers Genentech's low-affinity anti-TfR antibodies that facilitate BBB transcytosis without inhibiting transferrin or HFE binding; foundational patent on affinity-tuning TfR antibodies to escape lysosomal trapping and achieve CNS delivery.
therapeutic · vf_806ac99cdbc7ad59
Reducing anti-TfR antibody affinity for transferrin receptor enhances receptor-mediated transcytosis and brain uptake; bispecific anti-TfR/BACE1 antibody lowers brain Aβ in mice after single systemic dose. Mechanistic foundation of the Brain Shuttle delivery class.
therapeutic · vf_a0f9919e6d163b8d
Reducing the affinity of an antibody for the transferrin receptor (TfR) enhances its receptor-mediated transcytosis across the blood-brain barrier (BBB) into the mouse brain.
mechanism · vf_c3d9e665f63f045e
High-affinity anti-TfR antibodies remain associated with the blood-brain barrier vasculature, whereas lower-affinity variants are released into the brain parenchyma.
observational · vf_c7f8be49ea6547d8

Evidence atoms

vea_00c44b9dcdd344b7experimental · supports
Reducing the affinity of an antibody for the transferrin receptor (TfR) enhances its receptor-mediated transcytosis across the blood-brain barrier (BBB) into the mouse brain.
vea_413c78fe9dd802a5experimental · supports
High-affinity anti-TfR antibodies remain associated with the blood-brain barrier vasculature, whereas lower-affinity variants are released into the brain parenchyma.

Review, event, and evaluation records

events

vev_310f0a38204e8575finding.asserted
Manual finding added to frontier state
reviewer:will-blair-bot · 2026-05-06
vev_81f5607a5bcb6152finding.asserted
Manual finding added to frontier state
reviewer:will-blair-bot · 2026-05-06
vev_82932ecc6fce6211finding.asserted
Manual finding added to frontier state
reviewer:will-blair-bot · 2026-05-06
vev_ba1237c010601c63finding.asserted
Manual finding added to frontier state
reviewer:will-blair-bot · 2026-05-06
vev_fe5601397b60c040finding.reviewed
Accepted as a broad-frontier seed inside the anti-amyloid scope; source locator remains the authority.
reviewer:will-blair-bot · 2026-05-06

reviewable changes

vpr_073fe27e3062e803finding.review
Accepted as a broad-frontier seed inside the anti-amyloid scope; source locator remains the authority.
applied · reviewer:will-blair-bot · 2026-05-06
vpr_16a864c07facc4b8finding.add
Manual finding added to frontier state
applied · reviewer:will-blair-bot · 2026-05-06
vpr_1baa2624cf41beccfinding.add
Manual finding added to frontier state
applied · reviewer:will-blair-bot · 2026-05-06
vpr_3969c44c787e15e6finding.add
Manual finding added to frontier state
applied · reviewer:will-blair-bot · 2026-05-06
vpr_eb5bb753c55ac69cfinding.add
Manual finding added to frontier state
applied · reviewer:will-blair-bot · 2026-05-06

evaluations

No evaluation rows are attached.

vs_aae94d67e282b304 · source

Search Canopus

declared

4 findings

2 atoms

5 events

Bound findings

Evidence atoms

Review, event, and evaluation records

declared

4 findings

2 atoms

5 events

Bound findings

Evidence atoms

Review, event, and evaluation records