evidence boundary
unknownobservational
An evidence atom is an inspectable support unit. It is not a finding by itself; it supports or challenges a finding through review.
frontiers / frontier
Evidence atom
back to sourcesevidence boundary
unknownAn evidence atom is an inspectable support unit. It is not a finding by itself; it supports or challenges a finding through review.
finding binding
boundPediatric SHH-medulloblastoma carrying TP53 mutations (germline or somatic) has poor prognosis distinct from sporadic SHH-medulloblastoma; this stratification is now standard in WHO 2021 and informs trial enrollment for Li-Fraumeni syndrome surveillance.
inspect finding →
source binding
source-boundvs_169e023b6b2e5425
inspect source →
review context
unverified4 reviewable changes and 0 evaluation records target this atom or its bound objects.
Evidence statement
Pediatric SHH-medulloblastoma carrying TP53 mutations (germline or somatic) has poor prognosis distinct from sporadic SHH-medulloblastoma; this stratification is now standard in WHO 2021 and informs trial enrollment for Li-Fraumeni syndrome surveillance.
extraction method
manual_curation
support relation
unknown
condition refs
vcnd_0651caa48a09a98a
Caveats
events
vev_034755eea0b164f1finding.entity_resolvedExact NCBI Gene match for TP53; resolves entity-review debt without changing the finding assertion.
reviewer:solo-maintainer · 2026-05-20
vev_84fe1264ad385531finding.entity_resolvedExact MeSH match for medulloblastoma; resolves entity-review debt without changing the finding assertion.
reviewer:solo-maintainer · 2026-05-20
vev_855a5c8fa348fe2efinding.entity_resolvedExact NCBI Gene match for SHH; resolves pathway/entity-review debt without changing the finding assertion.
reviewer:solo-maintainer · 2026-05-20
vev_e5ce199aca875a76finding.assertedManual finding added to frontier state
agent:phgg-research-bot-2026-05-09 · 2026-05-09
reviewable changes
vpr_0653ea07892aaf1dfinding.entity_resolveExact MeSH match for medulloblastoma; resolves entity-review debt without changing the finding assertion.
applied · reviewer:solo-maintainer · 2026-05-20
vpr_122b9a0e42c69ad0finding.entity_resolveExact NCBI Gene match for SHH; resolves pathway/entity-review debt without changing the finding assertion.
applied · reviewer:solo-maintainer · 2026-05-20
vpr_a26c094cff505c76finding.entity_resolveExact NCBI Gene match for TP53; resolves entity-review debt without changing the finding assertion.
applied · reviewer:solo-maintainer · 2026-05-20
vpr_df503190d475f68efinding.addManual finding added to frontier state
applied · agent:phgg-research-bot-2026-05-09 · 2026-05-09
evaluations
No evaluation rows are attached.