evidence boundary
unknownobservational
An evidence atom is an inspectable support unit. It is not a finding by itself; it supports or challenges a finding through review.
frontiers / frontier
Evidence atom
back to sourcesevidence boundary
unknownAn evidence atom is an inspectable support unit. It is not a finding by itself; it supports or challenges a finding through review.
finding binding
boundPediatric high-grade glioma in NF1 patients (neurofibromatosis type 1) often arises in optic pathway and may behave more indolently than sporadic HGG; mechanistic drivers include NF1-loss-induced RAS hyperactivity, with selumetinib showing efficacy in this molecular setting (Fangusaro 2019).
inspect finding →
source binding
source-boundvs_067281016d0b1551
inspect source →
review context
unverified4 reviewable changes and 0 evaluation records target this atom or its bound objects.
Evidence statement
Pediatric high-grade glioma in NF1 patients (neurofibromatosis type 1) often arises in optic pathway and may behave more indolently than sporadic HGG; mechanistic drivers include NF1-loss-induced RAS hyperactivity, with selumetinib showing efficacy in this molecular setting (Fangusaro 2019).
extraction method
manual_curation
support relation
unknown
condition refs
vcnd_6eeb72abf0574d24
Caveats
events
vev_24bb6724fe7f6266finding.entity_resolvedv0.351 solo-maintainer brain-tumor translation wave: exact public identifier match; clears needs_review without changing the assertion.
reviewer:solo-maintainer · 2026-05-21
vev_485ef8795960ca4afinding.entity_resolvedv0.351 solo-maintainer brain-tumor translation wave: exact public identifier match; clears needs_review without changing the assertion.
reviewer:solo-maintainer · 2026-05-21
vev_4e7730c5510541d5finding.entity_resolvedv0.351 solo-maintainer brain-tumor translation wave: exact public identifier match; clears needs_review without changing the assertion.
reviewer:solo-maintainer · 2026-05-21
vev_63191967dc5fb4c1finding.assertedManual finding added to frontier state
agent:phgg-research-bot-2026-05-09 · 2026-05-09
reviewable changes
vpr_80c727163c797b43finding.entity_resolvev0.351 solo-maintainer brain-tumor translation wave: exact public identifier match; clears needs_review without changing the assertion.
applied · reviewer:solo-maintainer · 2026-05-21
vpr_9b34cc87ccd486a6finding.entity_resolvev0.351 solo-maintainer brain-tumor translation wave: exact public identifier match; clears needs_review without changing the assertion.
applied · reviewer:solo-maintainer · 2026-05-21
vpr_ac67cef6bbfbcf12finding.addManual finding added to frontier state
applied · agent:phgg-research-bot-2026-05-09 · 2026-05-09
vpr_c8943182ed9eb7dffinding.entity_resolvev0.351 solo-maintainer brain-tumor translation wave: exact public identifier match; clears needs_review without changing the assertion.
applied · reviewer:solo-maintainer · 2026-05-21
evaluations
No evaluation rows are attached.