record state
frontier-ownedReview status
This finding is part of accepted frontier state. Review events, reviewable changes, and proof state explain how it can change.
unreviewed
frontiers / frontier
Finding bundle
back to stateno incoming links yet
record state
frontier-ownedThis finding is part of accepted frontier state. Review events, reviewable changes, and proof state explain how it can change.
finding statement
finding type[object Object] · [object Object] · [object Object]
evidence
source-boundobservational · manual state transition
proof impact
packet context4 reviewable changes and 0 evaluation records are attached to this finding id.
Evidence and conditions
method
manual state transition
evidence type
observational
conditions
Provenance
source title
Fangusaro et al. Lancet Oncol 2019 (selumetinib NF1-LGG); Helfferich et al. Pediatr Drugs 2016
authors
agent:phgg-research-bot-2026-05-09
Pediatric high-grade glioma in NF1 patients (neurofibromatosis type 1) often arises in optic pathway and may behave more indolently than sporadic HGG; mechanistic drivers include NF1-loss-induced RAS hyperactivity, with selumetinib showing efficacy in this molecular setting (Fangusaro 2019).
vs_067281016d0b1551 · manual_curation
outgoing
No outgoing links.
incoming
No incoming links.
events
vev_24bb6724fe7f6266finding.entity_resolvedv0.351 solo-maintainer brain-tumor translation wave: exact public identifier match; clears needs_review without changing the assertion.
reviewer:solo-maintainer · 2026-05-21
vev_485ef8795960ca4afinding.entity_resolvedv0.351 solo-maintainer brain-tumor translation wave: exact public identifier match; clears needs_review without changing the assertion.
reviewer:solo-maintainer · 2026-05-21
vev_4e7730c5510541d5finding.entity_resolvedv0.351 solo-maintainer brain-tumor translation wave: exact public identifier match; clears needs_review without changing the assertion.
reviewer:solo-maintainer · 2026-05-21
vev_63191967dc5fb4c1finding.assertedManual finding added to frontier state
agent:phgg-research-bot-2026-05-09 · 2026-05-09
reviewable changes
vpr_80c727163c797b43finding.entity_resolvev0.351 solo-maintainer brain-tumor translation wave: exact public identifier match; clears needs_review without changing the assertion.
applied · reviewer:solo-maintainer · 2026-05-21
vpr_9b34cc87ccd486a6finding.entity_resolvev0.351 solo-maintainer brain-tumor translation wave: exact public identifier match; clears needs_review without changing the assertion.
applied · reviewer:solo-maintainer · 2026-05-21
vpr_ac67cef6bbfbcf12finding.addManual finding added to frontier state
applied · agent:phgg-research-bot-2026-05-09 · 2026-05-09
vpr_c8943182ed9eb7dffinding.entity_resolvev0.351 solo-maintainer brain-tumor translation wave: exact public identifier match; clears needs_review without changing the assertion.
applied · reviewer:solo-maintainer · 2026-05-21
evaluations
No evaluation record targets this finding id.