source boundary
frontier-owneddeclared
A source record is provenance. It supports a finding only through evidence atoms, extraction spans, and reviewed finding bundles.
frontiers / frontier
Source record
back to sourcessource boundary
frontier-ownedA source record is provenance. It supports a finding only through evidence atoms, extraction spans, and reviewed finding bundles.
finding bindings
record contextFindings bound to this source through source ids, evidence atoms, provenance, or reviewed source-record slots.
evidence atoms
materializedEvidence atoms pin exact spans, measurements, selectors, or curation assertions to the source.
review context
inspectable4 reviewable changes and 0 evaluations are attached through this source or its findings.
Locator and citation
locator
title:Fangusaro et al. Lancet Oncol 2019 (selumetinib NF1-LGG); Helfferich et al. Pediatr Drugs 2016
imported
2026-05-09T22:22:26.039693+00:00
extraction mode
manual_curation
authors
agent:phgg-research-bot-2026-05-09
Caveats
No source-specific caveats are recorded.
observational · vf_746329b3a240315c
Pediatric high-grade glioma in NF1 patients (neurofibromatosis type 1) often arises in optic pathway and may behave more indolently than sporadic HGG; mechanistic drivers include NF1-loss-induced RAS hyperactivity, with selumetinib showing efficacy in this molecular setting (Fangusaro 2019).
events
vev_24bb6724fe7f6266finding.entity_resolvedv0.351 solo-maintainer brain-tumor translation wave: exact public identifier match; clears needs_review without changing the assertion.
reviewer:solo-maintainer · 2026-05-21
vev_485ef8795960ca4afinding.entity_resolvedv0.351 solo-maintainer brain-tumor translation wave: exact public identifier match; clears needs_review without changing the assertion.
reviewer:solo-maintainer · 2026-05-21
vev_4e7730c5510541d5finding.entity_resolvedv0.351 solo-maintainer brain-tumor translation wave: exact public identifier match; clears needs_review without changing the assertion.
reviewer:solo-maintainer · 2026-05-21
vev_63191967dc5fb4c1finding.assertedManual finding added to frontier state
agent:phgg-research-bot-2026-05-09 · 2026-05-09
reviewable changes
vpr_80c727163c797b43finding.entity_resolvev0.351 solo-maintainer brain-tumor translation wave: exact public identifier match; clears needs_review without changing the assertion.
applied · reviewer:solo-maintainer · 2026-05-21
vpr_9b34cc87ccd486a6finding.entity_resolvev0.351 solo-maintainer brain-tumor translation wave: exact public identifier match; clears needs_review without changing the assertion.
applied · reviewer:solo-maintainer · 2026-05-21
vpr_ac67cef6bbfbcf12finding.addManual finding added to frontier state
applied · agent:phgg-research-bot-2026-05-09 · 2026-05-09
vpr_c8943182ed9eb7dffinding.entity_resolvev0.351 solo-maintainer brain-tumor translation wave: exact public identifier match; clears needs_review without changing the assertion.
applied · reviewer:solo-maintainer · 2026-05-21
evaluations
No evaluation rows are attached.