evidence boundary
unknowntheoretical
An evidence atom is an inspectable support unit. It is not a finding by itself; it supports or challenges a finding through review.
frontiers / frontier
Evidence atom
back to sourcesevidence boundary
unknownAn evidence atom is an inspectable support unit. It is not a finding by itself; it supports or challenges a finding through review.
finding binding
boundH3K27M disrupts PRC2-mediated H3K27 trimethylation globally via sequestration of the complex at poised enhancers, causing epigenetic dysregulation and altered chromatin compaction; ONC201 reversal of H3K27M phenotype operates through ClpP-stress, not PRC2 restoration.
inspect finding →
source binding
source-boundvs_ddb455de384593c1
inspect source →
review context
unverified1 reviewable changes and 0 evaluation records target this atom or its bound objects.
Evidence statement
H3K27M disrupts PRC2-mediated H3K27 trimethylation globally via sequestration of the complex at poised enhancers, causing epigenetic dysregulation and altered chromatin compaction; ONC201 reversal of H3K27M phenotype operates through ClpP-stress, not PRC2 restoration.
extraction method
manual_curation
support relation
unknown
condition refs
vcnd_d85c37377ff6f009
Caveats
events
vev_5b0206702f4a18f5finding.assertedManual finding added to frontier state
reviewer:will-blair · 2026-05-29
reviewable changes
vpr_6e151967263e969afinding.addManual finding added to frontier state
applied · reviewer:will-blair · 2026-05-29
evaluations
No evaluation rows are attached.