record state
frontier-ownedReview status
This finding is part of accepted frontier state. Review events, reviewable changes, and proof state explain how it can change.
unreviewed
frontiers / frontier
Finding bundle
back to staterecord state
frontier-ownedThis finding is part of accepted frontier state. Review events, reviewable changes, and proof state explain how it can change.
finding statement
finding typeNo entity list is declared.
evidence
source-boundtheoretical · manual state transition
proof impact
packet context1 reviewable changes and 0 evaluation records are attached to this finding id.
Evidence and conditions
method
manual state transition
evidence type
theoretical
conditions
Provenance
source title
PRC2 structural and mechanistic studies; H3K27M epigenetic profiling
authors
reviewer:will-blair
H3K27M disrupts PRC2-mediated H3K27 trimethylation globally via sequestration of the complex at poised enhancers, causing epigenetic dysregulation and altered chromatin compaction; ONC201 reversal of H3K27M phenotype operates through ClpP-stress, not PRC2 restoration.
vs_ddb455de384593c1 · manual_curation
outgoing
No outgoing links.
incoming
contradicts · vf_d2ead0145a97a4f1
extends · vf_313769b4fba6a0bb
events
vev_5b0206702f4a18f5finding.assertedManual finding added to frontier state
reviewer:will-blair · 2026-05-29
reviewable changes
vpr_6e151967263e969afinding.addManual finding added to frontier state
applied · reviewer:will-blair · 2026-05-29
evaluations
No evaluation record targets this finding id.