source boundary
frontier-owneddeclared
A source record is provenance. It supports a finding only through evidence atoms, extraction spans, and reviewed finding bundles.
frontiers / frontier
Source record
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frontier-ownedA source record is provenance. It supports a finding only through evidence atoms, extraction spans, and reviewed finding bundles.
finding bindings
record contextFindings bound to this source through source ids, evidence atoms, provenance, or reviewed source-record slots.
evidence atoms
materializedEvidence atoms pin exact spans, measurements, selectors, or curation assertions to the source.
review context
inspectable1 reviewable changes and 0 evaluations are attached through this source or its findings.
Locator and citation
external sourcelocator
title:PRC2 structural and mechanistic studies; H3K27M epigenetic profiling
imported
2026-05-29T02:50:57.653159+00:00
extraction mode
manual_curation
authors
reviewer:will-blair
Caveats
No source-specific caveats are recorded.
H3K27M disrupts PRC2-mediated H3K27 trimethylation globally via sequestration of the complex at poised enhancers, causing epigenetic dysregulation and altered chromatin compaction; ONC201 reversal of H3K27M phenotype operates through ClpP-stress, not PRC2 restoration.
events
vev_5b0206702f4a18f5finding.assertedManual finding added to frontier state
reviewer:will-blair · 2026-05-29
reviewable changes
vpr_6e151967263e969afinding.addManual finding added to frontier state
applied · reviewer:will-blair · 2026-05-29
evaluations
No evaluation rows are attached.