evidence boundary
unknownobservational
An evidence atom is an inspectable support unit. It is not a finding by itself; it supports or challenges a finding through review.
frontiers / frontier
Evidence atom
back to sourcesevidence boundary
unknownAn evidence atom is an inspectable support unit. It is not a finding by itself; it supports or challenges a finding through review.
finding binding
boundPediatric tumor mutational burden is significantly lower than adult tumor mutational burden across CNS tumor types; the corollary is that immune checkpoint inhibitor monotherapy is even less likely to be effective in pediatric brain tumors than in adult ones, except for rare cases of constitutional MMR deficiency (CMMRD) where TMB is markedly elevated.
inspect finding →
source binding
source-boundvs_7f70fa23926a81c1
inspect source →
review context
unverified1 reviewable changes and 0 evaluation records target this atom or its bound objects.
Evidence statement
Pediatric tumor mutational burden is significantly lower than adult tumor mutational burden across CNS tumor types; the corollary is that immune checkpoint inhibitor monotherapy is even less likely to be effective in pediatric brain tumors than in adult ones, except for rare cases of constitutional MMR deficiency (CMMRD) where TMB is markedly elevated.
extraction method
manual_curation
support relation
unknown
condition refs
vcnd_55a28479eb01b6ec
Caveats
events
vev_9bf8be8ced959cadfinding.assertedManual finding added to frontier state
agent:phgg-research-bot-2026-05-09 · 2026-05-09
reviewable changes
vpr_5a869e8750429ce8finding.addManual finding added to frontier state
applied · agent:phgg-research-bot-2026-05-09 · 2026-05-09
evaluations
No evaluation rows are attached.