source boundary
frontier-owneddeclared
A source record is provenance. It supports a finding only through evidence atoms, extraction spans, and reviewed finding bundles.
frontiers / frontier
Source record
back to sourcessource boundary
frontier-ownedA source record is provenance. It supports a finding only through evidence atoms, extraction spans, and reviewed finding bundles.
finding bindings
record contextFindings bound to this source through source ids, evidence atoms, provenance, or reviewed source-record slots.
evidence atoms
materializedEvidence atoms pin exact spans, measurements, selectors, or curation assertions to the source.
review context
inspectable1 reviewable changes and 0 evaluations are attached through this source or its findings.
Locator and citation
locator
title:Campbell et al. Cell 2017 (pediatric pan-cancer TMB); Bouffet et al. J Clin Oncol 2016 (CMMRD case)
imported
2026-05-09T22:23:08.387360+00:00
extraction mode
manual_curation
authors
agent:phgg-research-bot-2026-05-09
Caveats
No source-specific caveats are recorded.
Pediatric tumor mutational burden is significantly lower than adult tumor mutational burden across CNS tumor types; the corollary is that immune checkpoint inhibitor monotherapy is even less likely to be effective in pediatric brain tumors than in adult ones, except for rare cases of constitutional MMR deficiency (CMMRD) where TMB is markedly elevated.
events
vev_9bf8be8ced959cadfinding.assertedManual finding added to frontier state
agent:phgg-research-bot-2026-05-09 · 2026-05-09
reviewable changes
vpr_5a869e8750429ce8finding.addManual finding added to frontier state
applied · agent:phgg-research-bot-2026-05-09 · 2026-05-09
evaluations
No evaluation rows are attached.