evidence boundary
unknownexperimental
An evidence atom is an inspectable support unit. It is not a finding by itself; it supports or challenges a finding through review.
frontiers / frontier
Evidence atom
back to sourcesevidence boundary
unknownAn evidence atom is an inspectable support unit. It is not a finding by itself; it supports or challenges a finding through review.
finding binding
boundEZH2 inhibition (tazemetostat, valemetostat) and HDAC inhibition (panobinostat, vorinostat) have been studied in pediatric H3K27M glioma based on the H3K27M-induced PRC2 dysfunction; clinical activity has been modest and the epigenetic-targeting class is largely supplanted by ONC201 in current trial design.
inspect finding →
source binding
source-boundvs_e920e5a3f2e4a545
inspect source →
review context
unverified1 reviewable changes and 0 evaluation records target this atom or its bound objects.
Evidence statement
EZH2 inhibition (tazemetostat, valemetostat) and HDAC inhibition (panobinostat, vorinostat) have been studied in pediatric H3K27M glioma based on the H3K27M-induced PRC2 dysfunction; clinical activity has been modest and the epigenetic-targeting class is largely supplanted by ONC201 in current trial design.
extraction method
manual_curation
support relation
unknown
condition refs
vcnd_7a919098d19b4da6
Caveats
events
vev_7abe7ff19a537283finding.assertedManual finding added to frontier state
agent:phgg-research-bot-2026-05-09 · 2026-05-09
reviewable changes
vpr_1ccfe971c8bb4395finding.addManual finding added to frontier state
applied · agent:phgg-research-bot-2026-05-09 · 2026-05-09
evaluations
No evaluation rows are attached.