record state
frontier-ownedReview status
This finding is part of accepted frontier state. Review events, reviewable changes, and proof state explain how it can change.
unreviewed
frontiers / frontier
Finding bundle
back to stateno incoming links yet
record state
frontier-ownedThis finding is part of accepted frontier state. Review events, reviewable changes, and proof state explain how it can change.
finding statement
finding type[object Object] · [object Object] · [object Object]
evidence
source-boundexperimental · manual state transition; control details require source inspection
proof impact
packet context1 reviewable changes and 0 evaluation records are attached to this finding id.
Evidence and conditions
method
manual state transition; control details require source inspection
evidence type
experimental
conditions
Provenance
source title
Hashizume et al. Nat Med 2014; review: Vitanza et al. Curr Treat Options Oncol 2019
authors
agent:phgg-research-bot-2026-05-09
EZH2 inhibition (tazemetostat, valemetostat) and HDAC inhibition (panobinostat, vorinostat) have been studied in pediatric H3K27M glioma based on the H3K27M-induced PRC2 dysfunction; clinical activity has been modest and the epigenetic-targeting class is largely supplanted by ONC201 in current trial design.
vs_e920e5a3f2e4a545 · manual_curation
outgoing
No outgoing links.
incoming
No incoming links.
events
vev_7abe7ff19a537283finding.assertedManual finding added to frontier state
agent:phgg-research-bot-2026-05-09 · 2026-05-09
reviewable changes
vpr_1ccfe971c8bb4395finding.addManual finding added to frontier state
applied · agent:phgg-research-bot-2026-05-09 · 2026-05-09
evaluations
No evaluation record targets this finding id.