source boundary
frontier-owneddeclared
A source record is provenance. It supports a finding only through evidence atoms, extraction spans, and reviewed finding bundles.
frontiers / frontier
Source record
back to sourcessource boundary
frontier-ownedA source record is provenance. It supports a finding only through evidence atoms, extraction spans, and reviewed finding bundles.
finding bindings
record contextFindings bound to this source through source ids, evidence atoms, provenance, or reviewed source-record slots.
evidence atoms
materializedEvidence atoms pin exact spans, measurements, selectors, or curation assertions to the source.
review context
inspectable1 reviewable changes and 0 evaluations are attached through this source or its findings.
Locator and citation
locator
title:Hashizume et al. Nat Med 2014; review: Vitanza et al. Curr Treat Options Oncol 2019
imported
2026-05-09T22:03:16.919896+00:00
extraction mode
manual_curation
authors
agent:phgg-research-bot-2026-05-09
Caveats
No source-specific caveats are recorded.
EZH2 inhibition (tazemetostat, valemetostat) and HDAC inhibition (panobinostat, vorinostat) have been studied in pediatric H3K27M glioma based on the H3K27M-induced PRC2 dysfunction; clinical activity has been modest and the epigenetic-targeting class is largely supplanted by ONC201 in current trial design.
events
vev_7abe7ff19a537283finding.assertedManual finding added to frontier state
agent:phgg-research-bot-2026-05-09 · 2026-05-09
reviewable changes
vpr_1ccfe971c8bb4395finding.addManual finding added to frontier state
applied · agent:phgg-research-bot-2026-05-09 · 2026-05-09
evaluations
No evaluation rows are attached.