record state
frontier-ownedReview status
This finding is part of accepted frontier state. Review events, reviewable changes, and proof state explain how it can change.
unreviewed
frontiers / frontier
Finding bundle
back to stateno incoming links yet
record state
frontier-ownedThis finding is part of accepted frontier state. Review events, reviewable changes, and proof state explain how it can change.
finding statement
finding typeNo entity list is declared.
evidence
source-boundtheoretical · manual state transition
proof impact
packet context1 reviewable changes and 0 evaluation records are attached to this finding id.
Evidence and conditions
method
manual state transition
evidence type
theoretical
conditions
Provenance
source title
Pediatric Diffuse Midline Glioma H3K27-Altered (PMC11120159)
authors
reviewer:will-blair
H3K27M mutations (lysine-to-methionine substitutions at position 27 of histone H3.3 or H3.1) are present in 80-90% of diffuse midline gliomas and diffuse intrinsic pontine gliomas, occurring as early somatic events during pons development
vs_f982c1eecb59e377 · manual_curation
outgoing
vf_e38529682f65a609H3K27M presence enables the PRC2-inhibitory mechanism
vf_730821613735146bDespite molecular understanding, H3K27M-mutant gliomas have dismal median OS of 10-14 months, indicating existing therapies fail to address the core mechanism
incoming
No incoming links.
events
vev_20d4d2ecaa377834finding.assertedManual finding added to frontier state
reviewer:will-blair · 2026-05-29
reviewable changes
vpr_0f106eac487a4b6cfinding.addManual finding added to frontier state
applied · reviewer:will-blair · 2026-05-29
evaluations
No evaluation record targets this finding id.