record state
frontier-ownedReview status
This finding is part of accepted frontier state. Review events, reviewable changes, and proof state explain how it can change.
unreviewed
frontiers / frontier
Finding bundle
back to staterecord state
frontier-ownedThis finding is part of accepted frontier state. Review events, reviewable changes, and proof state explain how it can change.
finding statement
finding typeNo entity list is declared.
evidence
source-boundtheoretical · manual state transition
proof impact
packet context1 reviewable changes and 0 evaluation records are attached to this finding id.
Evidence and conditions
method
manual state transition
evidence type
theoretical
conditions
Provenance
source title
H3K27M induces defective chromatin spread of PRC2 (Nature Communications, s41467-019-09140-x)
authors
reviewer:will-blair
H3K27M acts as a dominant-negative inhibitor of PRC2, impeding genome-wide H3K27me3 and H3K27me2 spread while paradoxically retaining methylation at CpG island regions, creating a globally silenced epigenome with selective promoter derepression
vs_2f0309860c6b2d74 · manual_curation
outgoing
events
vev_0218d5b63f3661f8finding.assertedManual finding added to frontier state
reviewer:will-blair · 2026-05-29
reviewable changes
vpr_b8698eca4746480bfinding.addManual finding added to frontier state
applied · reviewer:will-blair · 2026-05-29
evaluations
No evaluation record targets this finding id.