record state
frontier-ownedReview status
This finding is part of accepted frontier state. Review events, reviewable changes, and proof state explain how it can change.
unreviewed
frontiers / frontier
Finding bundle
back to staterecord state
frontier-ownedThis finding is part of accepted frontier state. Review events, reviewable changes, and proof state explain how it can change.
finding statement
finding typeNo entity list is declared.
evidence
source-boundtheoretical · manual state transition
proof impact
packet context1 reviewable changes and 0 evaluation records are attached to this finding id.
Evidence and conditions
method
manual state transition
evidence type
theoretical
conditions
Provenance
source title
EZHIP inhibits PRC2 activity through H3K27M-like mechanism (Nature Communications, s41467-019-09981-6)
authors
reviewer:will-blair
H3K27M-driven gliomas exploit dual PRC2-inhibition mechanisms via the K27M oncohistone itself and EZHIP (PFA ependymoma-associated protein), which directly contact EZH2 catalytic site in structurally parallel fashion and stabilize narrow H3K27me3 peaks at CpG islands
vs_1fc2f41487432632 · manual_curation
outgoing
No outgoing links.
events
vev_514ecc6717f74858finding.assertedManual finding added to frontier state
reviewer:will-blair · 2026-05-29
reviewable changes
vpr_16ba5bc2fb0d2c02finding.addManual finding added to frontier state
applied · reviewer:will-blair · 2026-05-29
evaluations
No evaluation record targets this finding id.