source boundary
frontier-owneddeclared
A source record is provenance. It supports a finding only through evidence atoms, extraction spans, and reviewed finding bundles.
frontiers / frontier
Source record
back to sourcessource boundary
frontier-ownedA source record is provenance. It supports a finding only through evidence atoms, extraction spans, and reviewed finding bundles.
finding bindings
record contextFindings bound to this source through source ids, evidence atoms, provenance, or reviewed source-record slots.
evidence atoms
materializedEvidence atoms pin exact spans, measurements, selectors, or curation assertions to the source.
review context
inspectable1 reviewable changes and 0 evaluations are attached through this source or its findings.
Locator and citation
locator
title:EZHIP inhibits PRC2 activity through H3K27M-like mechanism (Nature Communications, s41467-019-09981-6)
imported
2026-05-29T02:50:57.341972+00:00
extraction mode
manual_curation
authors
reviewer:will-blair
Caveats
No source-specific caveats are recorded.
H3K27M-driven gliomas exploit dual PRC2-inhibition mechanisms via the K27M oncohistone itself and EZHIP (PFA ependymoma-associated protein), which directly contact EZH2 catalytic site in structurally parallel fashion and stabilize narrow H3K27me3 peaks at CpG islands
events
vev_514ecc6717f74858finding.assertedManual finding added to frontier state
reviewer:will-blair · 2026-05-29
reviewable changes
vpr_16ba5bc2fb0d2c02finding.addManual finding added to frontier state
applied · reviewer:will-blair · 2026-05-29
evaluations
No evaluation rows are attached.