source boundary
frontier-owneddeclared
A source record is provenance. It supports a finding only through evidence atoms, extraction spans, and reviewed finding bundles.
frontiers / frontier
Source record
back to sourcessource boundary
frontier-ownedA source record is provenance. It supports a finding only through evidence atoms, extraction spans, and reviewed finding bundles.
finding bindings
record contextFindings bound to this source through source ids, evidence atoms, provenance, or reviewed source-record slots.
evidence atoms
materializedEvidence atoms pin exact spans, measurements, selectors, or curation assertions to the source.
review context
inspectable1 reviewable changes and 0 evaluations are attached through this source or its findings.
Locator and citation
locator
title:An oncohistone-driven H3.3K27M/CREB5/ID1 axis maintains stemness (Nature Communications, s41467-025-58795-2)
imported
2026-05-29T02:50:57.399898+00:00
extraction mode
manual_curation
authors
reviewer:will-blair
Caveats
No source-specific caveats are recorded.
H3.3K27M drives context-dependent activation of the CREB5/ID1 axis via super-enhancer remodeling, maintaining stem-like transcriptional states; CREB5 inhibition or KDM6B targeting restores H3K27me3 and suppresses stemness in H3K27M-mutant cells
events
vev_1dbbac756b7a7eb4finding.assertedManual finding added to frontier state
reviewer:will-blair · 2026-05-29
reviewable changes
vpr_60a4a57ba1d6b2eefinding.addManual finding added to frontier state
applied · reviewer:will-blair · 2026-05-29
evaluations
No evaluation rows are attached.