evidence boundary
supportsobservational
An evidence atom is an inspectable support unit. It is not a finding by itself; it supports or challenges a finding through review.
frontiers / frontier
Evidence atom
back to sourcesevidence boundary
supportsAn evidence atom is an inspectable support unit. It is not a finding by itself; it supports or challenges a finding through review.
finding binding
boundClaudin-5 and occludin expression is reduced in cerebral microvasculature of early Alzheimer's disease post-mortem brain, paralleling the tight-junction breakdown observed in glioblastoma peritumoral vessels and consistent with a shared mechanism of BBB compromise across these otherwise unrelated diseases.
inspect finding →
source binding
source-boundvs_80b7c2dc8cc0347b
inspect source →
review context
unverified5 reviewable changes and 0 evaluation records target this atom or its bound objects.
Evidence statement
Cerebral microvasculature in early Alzheimer's disease post-mortem brain shows reduced expression of tight-junction proteins claudin-5 and occludin. Loss of these tight-junction components is consistent with a shared mechanism of blood-brain barrier compromise observed in other CNS pathologies including peritumoral glioma vasculature.
locator
section:Yamazaki 2019 abstract / Carrano 2011 Figure 3
extraction method
manual_curation
support relation
supports
condition refs
vcnd_e4a41d192bcc2d99
Caveats
No evidence-specific caveats are recorded.
events
vev_32642dcf29862edffinding.entity_resolvedWave A.2 curation: canonical entity resolution against standard ontologies (UniProt for proteins, MeSH for cell types and anatomical structures). All identifiers are unambiguous standard mappings.
reviewer:will-blair · 2026-05-10
vev_37c6ac65d30ce3b4finding.entity_resolvedWave A.2 curation: canonical entity resolution against standard ontologies (UniProt for proteins, MeSH for cell types and anatomical structures). All identifiers are unambiguous standard mappings.
reviewer:will-blair · 2026-05-10
vev_720a56b30dbe2909finding.entity_resolvedWave A.2 curation: canonical entity resolution against standard ontologies (UniProt for proteins, MeSH for cell types and anatomical structures). All identifiers are unambiguous standard mappings.
reviewer:will-blair · 2026-05-10
vev_767b027713665378finding.assertedManual finding added to frontier state
agent:bbb-curation-bot-2026-05-09 · 2026-05-09
vev_cd144b1e7c56413afinding.span_repairedWave A.3 curation: paraphrased span anchored to Yamazaki et al. Brain 2019 (tight-junction loss in AD post-mortem) and Carrano et al. Antioxid Redox Signal 2011 (oxidative-stress-mediated BBB tight-junction breakdown). Span is curator-paraphrased; cited paper sections are the load-bearing ones.
reviewer:will-blair · 2026-05-10
reviewable changes
vpr_21d0c76335044d59finding.entity_resolveWave A.2 curation: canonical entity resolution against standard ontologies (UniProt for proteins, MeSH for cell types and anatomical structures). All identifiers are unambiguous standard mappings.
applied · reviewer:will-blair · 2026-05-10
vpr_5d60f1d220d27332finding.entity_resolveWave A.2 curation: canonical entity resolution against standard ontologies (UniProt for proteins, MeSH for cell types and anatomical structures). All identifiers are unambiguous standard mappings.
applied · reviewer:will-blair · 2026-05-10
vpr_647281164d2a42d4finding.addManual finding added to frontier state
applied · agent:bbb-curation-bot-2026-05-09 · 2026-05-09
vpr_89fb94bdd3aee792finding.entity_resolveWave A.2 curation: canonical entity resolution against standard ontologies (UniProt for proteins, MeSH for cell types and anatomical structures). All identifiers are unambiguous standard mappings.
applied · reviewer:will-blair · 2026-05-10
vpr_c43731aea1eb7545finding.span_repairWave A.3 curation: paraphrased span anchored to Yamazaki et al. Brain 2019 (tight-junction loss in AD post-mortem) and Carrano et al. Antioxid Redox Signal 2011 (oxidative-stress-mediated BBB tight-junction breakdown). Span is curator-paraphrased; cited paper sections are the load-bearing ones.
applied · reviewer:will-blair · 2026-05-10
evaluations
No evaluation rows are attached.