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Anti-amyloid translation in Alzheimer's disease

CC-BY-4.0vfr_5076e7b3ff8e6b0f

id: vfr_5076e7b3ff8e6b0f
license: CC-BY-4.0
findings: 144
accepted core: 44
contested: 9

144

findings

links

125

sources

147

evidence

contested

0.63

avg conf

frontiers / frontier

Anti-amyloid translation in Alzheimer's disease

CC-BY-4.0vfr_5076e7b3ff8e6b0f

id: vfr_5076e7b3ff8e6b0f
license: CC-BY-4.0
findings: 144
accepted core: 44
contested: 9

144

findings

links

125

sources

147

evidence

contested

0.63

avg conf

Source record

back to sources

Yamazaki et al., Brain 2019; Carrano et al., Antioxid Redox Signal 2011

id: vs_80b7c2dc8cc0347b
frontier: Anti-amyloid translation in Alzheimer's disease
type: paper

source boundary

frontier-owned

declared

A source record is provenance. It supports a finding only through evidence atoms, extraction spans, and reviewed finding bundles.

finding bindings

record context

1 findings

Findings bound to this source through source ids, evidence atoms, provenance, or reviewed source-record slots.

evidence atoms

materialized

1 atoms

Evidence atoms pin exact spans, measurements, selectors, or curation assertions to the source.

review context

inspectable

5 events

5 reviewable changes and 0 evaluations are attached through this source or its findings.

Locator and citation

locator

title:Yamazaki et al., Brain 2019; Carrano et al., Antioxid Redox Signal 2011

imported

2026-05-09T21:02:21.022204+00:00

extraction mode

manual_curation

authors

agent:bbb-curation-bot-2026-05-09

Caveats

No source-specific caveats are recorded.

Bound findings

Claudin-5 and occludin expression is reduced in cerebral microvasculature of early Alzheimer's disease post-mortem brain, paralleling the tight-junction breakdown observed in glioblastoma peritumoral vessels and consistent with a shared mechanism of BBB compromise across these otherwise unrelated diseases.
mechanism · vf_155dd090fb7c6ff7

Evidence atoms

vea_8f5b4052182b3c22observational · supports
Cerebral microvasculature in early Alzheimer's disease post-mortem brain shows reduced expression of tight-junction proteins claudin-5 and occludin. Loss of these tight-junction components is consistent with a shared mechanism of blood-brain barrier compromise observed in other CNS pathologies including peritumoral glioma vasculature.

Review, event, and evaluation records

events

vev_32642dcf29862edffinding.entity_resolved
Wave A.2 curation: canonical entity resolution against standard ontologies (UniProt for proteins, MeSH for cell types and anatomical structures). All identifiers are unambiguous standard mappings.
reviewer:will-blair · 2026-05-10
vev_37c6ac65d30ce3b4finding.entity_resolved
Wave A.2 curation: canonical entity resolution against standard ontologies (UniProt for proteins, MeSH for cell types and anatomical structures). All identifiers are unambiguous standard mappings.
reviewer:will-blair · 2026-05-10
vev_720a56b30dbe2909finding.entity_resolved
Wave A.2 curation: canonical entity resolution against standard ontologies (UniProt for proteins, MeSH for cell types and anatomical structures). All identifiers are unambiguous standard mappings.
reviewer:will-blair · 2026-05-10
vev_767b027713665378finding.asserted
Manual finding added to frontier state
agent:bbb-curation-bot-2026-05-09 · 2026-05-09
vev_cd144b1e7c56413afinding.span_repaired
Wave A.3 curation: paraphrased span anchored to Yamazaki et al. Brain 2019 (tight-junction loss in AD post-mortem) and Carrano et al. Antioxid Redox Signal 2011 (oxidative-stress-mediated BBB tight-junction breakdown). Span is curator-paraphrased; cited paper sections are the load-bearing ones.
reviewer:will-blair · 2026-05-10

reviewable changes

vpr_21d0c76335044d59finding.entity_resolve
Wave A.2 curation: canonical entity resolution against standard ontologies (UniProt for proteins, MeSH for cell types and anatomical structures). All identifiers are unambiguous standard mappings.
applied · reviewer:will-blair · 2026-05-10
vpr_5d60f1d220d27332finding.entity_resolve
Wave A.2 curation: canonical entity resolution against standard ontologies (UniProt for proteins, MeSH for cell types and anatomical structures). All identifiers are unambiguous standard mappings.
applied · reviewer:will-blair · 2026-05-10
vpr_647281164d2a42d4finding.add
Manual finding added to frontier state
applied · agent:bbb-curation-bot-2026-05-09 · 2026-05-09
vpr_89fb94bdd3aee792finding.entity_resolve
Wave A.2 curation: canonical entity resolution against standard ontologies (UniProt for proteins, MeSH for cell types and anatomical structures). All identifiers are unambiguous standard mappings.
applied · reviewer:will-blair · 2026-05-10
vpr_c43731aea1eb7545finding.span_repair
Wave A.3 curation: paraphrased span anchored to Yamazaki et al. Brain 2019 (tight-junction loss in AD post-mortem) and Carrano et al. Antioxid Redox Signal 2011 (oxidative-stress-mediated BBB tight-junction breakdown). Span is curator-paraphrased; cited paper sections are the load-bearing ones.
applied · reviewer:will-blair · 2026-05-10

evaluations

No evaluation rows are attached.

Source record

back to sources

Yamazaki et al., Brain 2019; Carrano et al., Antioxid Redox Signal 2011

id: vs_80b7c2dc8cc0347b
frontier: Anti-amyloid translation in Alzheimer's disease
type: paper

source boundary

frontier-owned

declared

A source record is provenance. It supports a finding only through evidence atoms, extraction spans, and reviewed finding bundles.

finding bindings

record context

1 findings

Findings bound to this source through source ids, evidence atoms, provenance, or reviewed source-record slots.

evidence atoms

materialized

1 atoms

Evidence atoms pin exact spans, measurements, selectors, or curation assertions to the source.

review context

inspectable

5 events

5 reviewable changes and 0 evaluations are attached through this source or its findings.

Locator and citation

locator

title:Yamazaki et al., Brain 2019; Carrano et al., Antioxid Redox Signal 2011

imported

2026-05-09T21:02:21.022204+00:00

extraction mode

manual_curation

authors

agent:bbb-curation-bot-2026-05-09

Caveats

No source-specific caveats are recorded.

Bound findings

Claudin-5 and occludin expression is reduced in cerebral microvasculature of early Alzheimer's disease post-mortem brain, paralleling the tight-junction breakdown observed in glioblastoma peritumoral vessels and consistent with a shared mechanism of BBB compromise across these otherwise unrelated diseases.
mechanism · vf_155dd090fb7c6ff7

Evidence atoms

vea_8f5b4052182b3c22observational · supports
Cerebral microvasculature in early Alzheimer's disease post-mortem brain shows reduced expression of tight-junction proteins claudin-5 and occludin. Loss of these tight-junction components is consistent with a shared mechanism of blood-brain barrier compromise observed in other CNS pathologies including peritumoral glioma vasculature.

Review, event, and evaluation records

events

vev_32642dcf29862edffinding.entity_resolved
Wave A.2 curation: canonical entity resolution against standard ontologies (UniProt for proteins, MeSH for cell types and anatomical structures). All identifiers are unambiguous standard mappings.
reviewer:will-blair · 2026-05-10
vev_37c6ac65d30ce3b4finding.entity_resolved
Wave A.2 curation: canonical entity resolution against standard ontologies (UniProt for proteins, MeSH for cell types and anatomical structures). All identifiers are unambiguous standard mappings.
reviewer:will-blair · 2026-05-10
vev_720a56b30dbe2909finding.entity_resolved
Wave A.2 curation: canonical entity resolution against standard ontologies (UniProt for proteins, MeSH for cell types and anatomical structures). All identifiers are unambiguous standard mappings.
reviewer:will-blair · 2026-05-10
vev_767b027713665378finding.asserted
Manual finding added to frontier state
agent:bbb-curation-bot-2026-05-09 · 2026-05-09
vev_cd144b1e7c56413afinding.span_repaired
Wave A.3 curation: paraphrased span anchored to Yamazaki et al. Brain 2019 (tight-junction loss in AD post-mortem) and Carrano et al. Antioxid Redox Signal 2011 (oxidative-stress-mediated BBB tight-junction breakdown). Span is curator-paraphrased; cited paper sections are the load-bearing ones.
reviewer:will-blair · 2026-05-10

reviewable changes

vpr_21d0c76335044d59finding.entity_resolve
Wave A.2 curation: canonical entity resolution against standard ontologies (UniProt for proteins, MeSH for cell types and anatomical structures). All identifiers are unambiguous standard mappings.
applied · reviewer:will-blair · 2026-05-10
vpr_5d60f1d220d27332finding.entity_resolve
Wave A.2 curation: canonical entity resolution against standard ontologies (UniProt for proteins, MeSH for cell types and anatomical structures). All identifiers are unambiguous standard mappings.
applied · reviewer:will-blair · 2026-05-10
vpr_647281164d2a42d4finding.add
Manual finding added to frontier state
applied · agent:bbb-curation-bot-2026-05-09 · 2026-05-09
vpr_89fb94bdd3aee792finding.entity_resolve
Wave A.2 curation: canonical entity resolution against standard ontologies (UniProt for proteins, MeSH for cell types and anatomical structures). All identifiers are unambiguous standard mappings.
applied · reviewer:will-blair · 2026-05-10
vpr_c43731aea1eb7545finding.span_repair
Wave A.3 curation: paraphrased span anchored to Yamazaki et al. Brain 2019 (tight-junction loss in AD post-mortem) and Carrano et al. Antioxid Redox Signal 2011 (oxidative-stress-mediated BBB tight-junction breakdown). Span is curator-paraphrased; cited paper sections are the load-bearing ones.
applied · reviewer:will-blair · 2026-05-10

evaluations

No evaluation rows are attached.

vs_80b7c2dc8cc0347b · source

Search Canopus

declared

1 findings

1 atoms

5 events

Bound findings

Evidence atoms

Review, event, and evaluation records

declared

1 findings

1 atoms

5 events

Bound findings

Evidence atoms

Review, event, and evaluation records